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Anorexiants

What are Anorexiants?

Anorexiants are drugs that act on the brain to suppress appetite. They have a stimulant effect on the hypothalamic and limbic regions, which control satiety. Anorexiants are used as therapy for obesity.
Phendimetrazine
Phendimetrazine is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an "anorectic" or "anorexigenic" drug. Phendimetrazine stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite.
Phendimetrazine is used as a short-term supplement to diet and exercise in the treatment of obesity.
 Phendimetrazine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Phendimetrazine may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.

Weight loss during pregnancy can harm an unborn baby, even if you are overweight. Do not use phendimetrazine if you are pregnant.

Usual Adult Dose for Obesity

Extended-release:
-105 mg orally once a day, 30 to 60 minutes before morning meal

Immediate-release:
-35 mg orally 2 or 3 times a day, one hour before meals
-Maximum dose: 70 mg orally 3 times a day, one hour before meals

Comments:
-For use as monotherapy only.
-Extended-release: The active drug in each extended release capsule approximates the action of three 35 mg immediate-release doses taken at 4 hour intervals.
-Immediate-release: Dosage should be individualized to obtain an adequate response with the lowest effective dose; 17.5 mg per dose may be adequate in some cases.

Use: Management of exogenous obesity as a short-term adjunct in a regimen of weight reduction based on caloric restriction in patients with
-an initial BMI of 30 kg/m2 or greater OR
-an initial BMI of 27 kg/m2 or greater in the presence of other risk factors (e.g., hypertension, diabetes, hyperlipidemia) who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone.

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